| 车次 | 始发站 | 始发时间 | 出发站 | 开车时间 | 到达站 | 到达时间 | 终点站 | 终到时间 |
| D5401 | 徐州东 | 06:06 | 宿迁 | 06:40 | 扬州东 | 07:50 | 南京 | 08:50 |
| D5404 | 徐州东 | 06:06 | 宿迁 | 06:40 | 扬州东 | 07:50 | 南京 | 08:50 |
| C3711 | 徐州东 | 07:00 | 宿迁 | 07:34 | 扬州 | 09:10 | 扬州 | 09:10 |
| G7587 | 徐州东 | 07:10 | 宿迁 | 07:50 | 扬州东 | 09:17 | 苍南 | 15:26 |
| G7643 | 徐州东 | 08:47 | 宿迁 | 09:21 | 扬州东 | 10:32 | 义乌 | 14:32 |
| D5405 | 徐州东 | 09:08 | 宿迁 | 09:54 | 扬州东 | 11:10 | 南京 | 12:17 |
| D5408 | 徐州东 | 09:08 | 宿迁 | 09:54 | 扬州东 | 11:10 | 南京 | 12:17 |
| G7559 | 徐州东 | 10:00 | 宿迁 | 10:34 | 扬州东 | 11:46 | 杭州东 | 15:13 |
| D5409 | 宿迁 | 11:18 | 宿迁 | 11:18 | 扬州东 | 12:27 | 南京 | 13:28 |
| D5412 | 宿迁 | 11:18 | 宿迁 | 11:18 | 扬州东 | 12:27 | 南京 | 13:28 |
| G8299 | 徐州东 | 11:00 | 宿迁 | 11:34 | 扬州东 | 12:44 | 上海 | 14:35 |
| G8265 | 睢宁 | 11:29 | 宿迁 | 11:44 | 扬州东 | 13:01 | 上海 | 15:07 |
| G2611 | 郑州东 | 09:24 | 宿迁 | 12:05 | 扬州东 | 13:22 | 上海虹桥 | 15:31 |
| G2614 | 郑州东 | 09:24 | 宿迁 | 12:05 | 扬州东 | 13:22 | 上海虹桥 | 15:31 |
| G2571 | 北京南 | 09:14 | 宿迁 | 13:00 | 扬州东 | 14:22 | 无锡 | 15:27 |
| G8277 | 宿迁 | 13:27 | 宿迁 | 13:27 | 扬州东 | 14:48 | 上海 | 17:12 |
| D5413 | 徐州东 | 13:03 | 宿迁 | 13:43 | 扬州东 | 15:16 | 南京 | 16:12 |
| D5416 | 徐州东 | 13:03 | 宿迁 | 13:43 | 扬州东 | 15:16 | 南京 | 16:12 |
| G2615 | 郑州东 | 13:34 | 宿迁 | 16:08 | 扬州东 | 17:24 | 上海 | 19:20 |
| G2618 | 郑州东 | 13:34 | 宿迁 | 16:08 | 扬州东 | 17:24 | 上海 | 19:20 |
| G8289 | 宿迁 | 16:59 | 宿迁 | 16:59 | 扬州东 | 18:03 | 上海 | 19:59 |
| G1985 | 郑州东 | 15:25 | 宿迁 | 18:06 | 扬州东 | 19:30 | 上海虹桥 | 21:41 |
| G1988 | 郑州东 | 15:25 | 宿迁 | 18:06 | 扬州东 | 19:30 | 上海虹桥 | 21:41 |
| D5471 | 徐州东 | 19:24 | 宿迁 | 20:10 | 扬州东 | 21:20 | 南京南 | 22:23 |
| D5474 | 徐州东 | 19:24 | 宿迁 | 20:10 | 扬州东 | 21:20 | 南京南 | 22:23 |
| D5475 | 宿迁 | 21:02 | 宿迁 | 21:02 | 扬州东 | 22:11 | 南京南 | 23:08 |
| G1595 | 北京南 | 17:27 | 宿迁 | 21:09 | 扬州 | 22:40 | 扬州 | 22:40 |